MAPK1, mitogen-activated protein kinase 1, 5594

N. diseases: 1059; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 PosttranslationalModification disease BEFREE ω-hydroxyundec-9-enoic acid induces apoptosis by ROS mediated JNK and p38 phosphorylation in breast cancer cell lines. 28681938 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 PosttranslationalModification disease BEFREE ω-hydroxyundec-9-enoic acid induces apoptosis by ROS mediated JNK and p38 phosphorylation in breast cancer cell lines. 28681938 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.090 Biomarker disease BEFREE β₂-Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another 'radical' road to heart failure? 21271996 2011
CUI: C0018801
Disease: Heart failure
Heart failure
0.070 Biomarker disease BEFREE β₂-Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another 'radical' road to heart failure? 21271996 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 Biomarker disease BEFREE β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma. 30874538 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression phenotype BEFREE β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. 28722351 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. 28722351 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker phenotype BEFREE β-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway. 30582718 2019
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological
0.010 Biomarker disease BEFREE β-Endorphin Induction by Psychological Stress Promotes Leydig Cell Apoptosis through p38 MAPK Pathway in Male Rats. 31623282 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE β-arrestin-2 is involved in irisin induced glucose metabolism in type 2 diabetes via p38 MAPK signaling. 28888936 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE α-SMA, p-ERK and p-JNK expression levels in tumoral and peritumoral tissues of HCC were assessed by immunohistochemical and western blotting. 28668554 2017
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.220 Therapeutic disease RGD [Effects of hydrogen sulfide on myocardial fibrosis and MAPK1/3 and MMP-8 expression in diabetic rats]. 25907942 2015
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer
0.200 Biomarker disease RGD [Effect of moxibustion intervention on expression of gastric epidermal growth factor receptor and extracellular signal regulated kinase 1/2 expression in rats with gastric ulcer]. 25518106 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker disease BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690 2019
Malignant neoplasm of colon and/or rectum
0.100 Biomarker disease BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.100 Biomarker disease BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone
0.100 Biomarker disease BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma
0.100 Biomarker disease BEFREE [Corrigendum] All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway. 31268160 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.090 AlteredExpression disease BEFREE Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression. 29518435 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.100 Biomarker disease BEFREE Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells. 19241161 2009
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.100 Biomarker disease BEFREE Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells. 19241161 2009
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.100 Biomarker disease BEFREE Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells. 19241161 2009
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.100 AlteredExpression disease BEFREE YB-1, phosphorylated YB-1 (p-YB-1), and ERK2 protein expressions in 165 clinical specimens of prostate cancer were investigated by immunohistochemistry. 23838318 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.100 AlteredExpression disease BEFREE YB-1, phosphorylated YB-1 (p-YB-1), and ERK2 protein expressions in 165 clinical specimens of prostate cancer were investigated by immunohistochemistry. 23838318 2013
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.090 Biomarker disease BEFREE Xin treatment significantly improved cardiac function and attenuated cardiac fibrosis by suppressing the p38 MAPK and TGF-ß1/Smad3 signaling pathway in CHF rats. 28100897 2017